IMP3

Across TCGA pan-cancer cohorts, IMP3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IMP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IMP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IMP3 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KIRC, LIHC, and BLCA are the cancer types where IMP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IMP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.648	<.001	12	view →
LIHC	Male	III,IV	+0.655	<.001	9	view →
BLCA	Male	IV	+1.165	.008	8	view →
STAD	All	II,III,IV	+0.640	<.001	8	view →
LUSC	Male	All	+0.422	<.001	6	view →
HNSC	Male	All	+0.397	.004	6	view →
BRCA	All	All	+0.195	.001	6	view →
CHOL	All	All	+0.984	<.001	5	view →
COAD	Female	II,III,IV	+0.424	<.001	5	view →
KICH	All	All	−0.551	<.001	4	view →
PRAD	All	All	+0.217	.010	2	view →
KIRP	All	All	−0.166	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IMP3–KIRC

Open the KIRC breakdown →