IL9R

Across TCGA cell cohorts, IL9R mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL9R-associated genes across cancer lineages are DEFA4, GOT1L1, and OR5A2. Each is linked with IL9R in more than 1 cancer types. Because this analysis shows association rather than direction, both IL9R-to-partner and partner-to-IL9R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by IL9R-low versus IL9R-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL9R→partner) and Y-score (partner→IL9R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFA4 →	+0.031	+4.662	<.001	.005	3	2
LUNG_NSCLC_LUAD	GOT1L1 →	+0.037	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR5A2 →	+0.005	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	UBE2U →	+0.191	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	SRY →	+0.062	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.027	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

DEFA4 by IL9R expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →