IL7R

Across TCGA pan-cancer cohorts, IL7R Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated IL7R data layer compared with 26 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher IL7R Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IL7R expression acts as an unfavorable survival marker.

ESCA, COAD, and BRCA are the cancer types where IL7R Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.164	0.702	.001	21	view →
COAD	OS	Median	IV	0.174	0.656	.007	17	view →
BRCA	OS	Median	III,IV	0.001	0.907	<.001	12	view →
LIHC	DFS	Median	All	0.034	0.556	<.001	12	view →
LGG	DFS	Median	All	0.156	0.753	<.001	6	view →
THCA	DFS	Median	II,III,IV	0.180	0.793	.008	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	OS	Median	II,III,IV	0.330	0.623	.030	3	view →
SKCM	DFS	Median	IV	0.016	0.541	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

IL7R–ESCA (OS)

Open the ESCA breakdown →