IL6ST

Across TCGA pan-cancer cohorts, IL6ST mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IL6ST’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL6ST mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IL6ST is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where IL6ST tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL6ST mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−0.542	<.001	11	view →
LSCC	Male	All	−1.277	<.001	9	view →
LUAD	Male	All	−0.573	<.001	9	view →
OV	All	All	−0.714	<.001	2	view →
CCRCC	All	All	+0.120	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IL6ST–HNSC

Open the HNSC breakdown →