IL6R

Across TCGA patient cohorts, IL6R RNA expression is significantly associated with the protein abundance of many other proteins, with 19,103 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IL6R-associated proteins across cancer lineages are PLCL2_S1113, RASSF5, and CLIC2. Each is linked with IL6R in more than 5 cancer types. Because this analysis shows association rather than direction, both IL6R-to-partner and partner-to-IL6R results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL6R versus PLCL2_S1113 in LSCC, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6R→partner) and Y-score (partner→IL6R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLCL2_S1113 →	+0.538	+0.442	<.001	.005	3	6
LSCC	RASSF5 →	+0.513	+0.730	<.001	<.001	3	6
LSCC	CLIC2 →	+0.513	+0.631	<.001	.001	3	6
LSCC	DOCK8_S451 →	+0.785	+0.604	<.001	.001	3	6
BRCA	SEPTIN1_S315 →	+0.856	+0.600	<.001	<.001	3	6
GBM	FYB1 →	+0.862	+0.844	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,103 associations by consensus.

IL6R vs PLCL2_S1113 — LSCC

Explore this scatter interactively →