IL6R

Across TCGA pan-cancer cohorts, IL6R RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IL6R data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IL6R RNA is associated with better overall survival. In most high-consensus cancer types, elevated IL6R expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

KIRC, MESO, and PAAD are the cancer types where IL6R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.711	0.554	<.001	114	view →
MESO	DFS	Tertile	All	0.482	0.271	<.001	57	view →
PAAD	OS	Tertile	All	0.731	0.531	.002	56	view →
LGG	OS	Quartile	All	0.389	0.751	<.001	37	view →
LAML	DFS	Median	All	0.416	0.713	.001	30	view →
SARC	OS	Median	All	0.834	0.617	<.001	25	view →
UVM	DFS	Quartile	III,IV	0.200	1.000	.006	17	view →
GBM	DFS	Tertile	All	0.185	0.261	.038	9	view →
OV	OS	Median	All	0.878	0.806	.013	8	view →
UCEC	OS	Quartile	III,IV	0.777	0.464	.024	8	view →
THCA	DFS	Tertile	IV	1.000	0.715	.032	7	view →
SCLC	DFS	Tertile	IV	0.110	0.489	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IL6R–KIRC (OS)

Open the KIRC breakdown →