IL6R

Across TCGA patient cohorts, IL6R mutation is significantly associated with the RNA expression of many other genes, with 844 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL6R-associated genes across cancer lineages are ATP5PBP4, MIR216A, and RNU6-1022P. Each is linked with IL6R in more than 1 cancer types. Because this analysis shows association rather than direction, both IL6R-to-partner and partner-to-IL6R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5PBP4 grouped by IL6R-low versus IL6R-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6R→partner) and Y-score (partner→IL6R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATP5PBP4 →	+0.058	+5.824	<.001	.001	3	2
BRCA	MIR216A →	+0.234	+7.731	<.001	.009	3	2
LUSC	RNU6-1022P →	+0.283	+7.924	<.001	.008	3	2
HNSC	RN7SKP144 →	+0.235	+6.339	<.001	.001	3	2
LUAD	RNU5A-4P →	+0.528	+3.690	<.001	.009	3	2
LUAD	RNU6-786P →	+0.785	+4.273	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 844 associations by consensus.

ATP5PBP4 by IL6R expression — COAD

Explore this box plot interactively →