IL6R

Across TCGA patient cohorts, IL6R mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL6R-associated genes across cancer lineages are FoxM1, PCNA, and STAT3_pY705. Each is linked with IL6R in more than 1 cancer types. Because this analysis shows association rather than direction, both IL6R-to-partner and partner-to-IL6R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by IL6R-low versus IL6R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6R→partner) and Y-score (partner→IL6R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.279	+3.009	.016	.019	3	1
UCEC	PCNA →	+0.297	+3.459	.002	.005	3	1
UCEC	STAT3_pY705 →	-0.322	-3.449	.006	.005	3	1
UCEC	Stathmin →	+0.127	+2.000	.039	.032	3	1
UCEC	ATM →	-0.564	-3.169	.005	.019	2	1
UCEC	Caspase-7-cleavedD198 →	+0.988	+3.341	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FoxM1 by IL6R expression — UCEC

Explore this box plot interactively →