IL6R

Across TCGA cell cohorts, IL6R RNA expression is significantly associated with the go_rna of many other GO terms, with 5,430 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL6R-associated GO terms across cancer lineages are Ensheathment of neurons, Axon ensheathment, and Vascular endothelial growth factor production. Each is linked with IL6R in more than 8 cancer types. Because this analysis shows association rather than direction, both IL6R-to-partner and partner-to-IL6R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ensheathment of neurons grouped by IL6R-low versus IL6R-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6R→partner) and Y-score (partner→IL6R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Ensheathment of neurons →	+0.110	+1.666	<.001	<.001	3	9
BONE	Axon ensheathment →	+0.110	+1.666	<.001	<.001	3	9
BONE	Vascular endothelial growth factor production →	-0.312	-2.051	<.001	<.001	3	8
BONE	Protein targeting to vacuole involved in autophagy →	+0.197	+1.608	<.001	<.001	3	8
BONE	Myelin maintenance →	+0.242	+1.566	<.001	<.001	3	8
SKIN	Positive regulation of lipid biosynthetic process →	+0.077	+1.445	.004	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,430 associations by consensus.

Ensheathment of neurons by IL6R expression — BONE

Explore this box plot interactively →