IL6R

Across TCGA cell cohorts, IL6R mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IL6R-associated genes across cancer lineages are GAGE12J, CFAP97D2, and OR13C4. Each is linked with IL6R in more than 1 cancer types. Because this analysis shows association rather than direction, both IL6R-to-partner and partner-to-IL6R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12J grouped by IL6R-low versus IL6R-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6R→partner) and Y-score (partner→IL6R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CFAP97D2 →	+0.020	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR13C4 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C2 →	+0.012	+4.887	.003	.009	3	1
SKIN	BHLHA9 →	+0.050	+4.273	<.001	.006	3	1
SKIN	NLRP2B →	+0.016	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GAGE12J by IL6R expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →