IL6-AS1

Across TCGA pan-cancer cohorts, IL6-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IL6-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IL6-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IL6-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

KIRC, STAD, and LGG are the cancer types where IL6-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.557	0.700	<.001	110	view →
STAD	DFS	Quartile	III,IV	0.525	0.756	.005	42	view →
LGG	DFS	Tertile	All	0.667	0.814	<.001	42	view →
KIRP	DFS	Median	All	0.587	0.901	.008	35	view →
LUSC	OS	Median	II,III,IV	0.542	0.718	<.001	33	view →
UVM	OS	Tertile	All	0.365	0.748	.010	28	view →
ACC	OS	Quartile	All	0.731	0.974	.012	16	view →
READ	DFS	Median	IV	0.179	0.936	.010	15	view →
SKCM	OS	Median	All	0.400	0.293	.021	14	view →
LUAD	OS	Quartile	II,III,IV	0.808	0.611	.030	7	view →
UCS	DFS	Median	IV	0.850	0.475	.023	6	view →
COAD	DFS	Median	IV	0.344	0.572	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IL6-AS1–KIRC (OS)

Open the KIRC breakdown →