IL6-AS1

Across TCGA pan-cancer cohorts, IL6-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IL6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where IL6-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types IL6-AS1 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

BRCA, BLCA, and KICH are the cancer types where IL6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−1.010	<.001	6	view →
BLCA	Female	IV	−0.366	.010	5	view →
KICH	All	All	−0.366	.005	4	view →
LIHC	All	All	+0.049	<.001	4	view →
LUSC	Female	All	−0.540	.002	2	view →
UCEC	All	All	−0.523	.023	2	view →
THCA	Male	III,IV	−0.178	.039	1	view →
CHOL	Female	All	+0.116	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IL6-AS1–BRCA

Open the BRCA breakdown →