IL5

Across TCGA patient cohorts, IL5 mutation is significantly associated with the RNA expression of many other genes, with 343 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL5-associated genes across cancer lineages are PPP2R2B-IT1, IGLVIV-53, and MIR508. Each is linked with IL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL5-to-partner and partner-to-IL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R2B-IT1 grouped by IL5-low versus IL5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL5→partner) and Y-score (partner→IL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PPP2R2B-IT1 →	+0.069	+7.640	<.001	.009	3	2
SKCM	IGLVIV-53 →	+0.094	+7.816	<.001	.008	3	1
BLCA	MIR508 →	+0.862	+7.640	<.001	.009	3	1
UCEC	ADM →	+1.050	+3.595	.009	.001	3	1
UCEC	ME3 →	-1.246	-3.574	<.001	.003	3	1
UCEC	TIAM1 →	-0.801	-3.435	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 343 associations by consensus.

PPP2R2B-IT1 by IL5 expression — BLCA

Explore this box plot interactively →