IL4R

Across TCGA patient cohorts, IL4R RNA expression is significantly associated with the protein abundance of many other proteins, with 22,312 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IL4R-associated proteins across cancer lineages are TRIM21, PPP1R18_S224, and SIPA1. Each is linked with IL4R in more than 6 cancer types. Because this analysis shows association rather than direction, both IL4R-to-partner and partner-to-IL4R results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL4R versus TRIM21 in HNSC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IL4R→partner) and Y-score (partner→IL4R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM21 →	+0.627	+0.836	<.001	<.001	3	7
LSCC	PPP1R18_S224 →	+0.563	+0.663	<.001	<.001	3	6
GBM	SIPA1 →	+0.350	+1.072	<.001	<.001	3	6
HNSC	IFI35 →	+0.417	+0.736	<.001	<.001	3	6
GBM	JUNB →	+0.417	+0.899	<.001	<.001	3	6
OV	SSB →	-0.402	-1.150	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,312 associations by consensus.

IL4R vs TRIM21 — HNSC

Explore this scatter interactively →