IL4R

Across TCGA pan-cancer cohorts, IL4R RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IL4R data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IL4R RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IL4R expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCS show a favorable association.

KIRP, LGG, and LUSC are the cancer types where IL4R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	II,III,IV	0.203	0.833	.002	49	view →
LGG	DFS	Median	All	0.333	0.501	<.001	47	view →
LUSC	DFS	Median	All	0.265	0.467	<.001	39	view →
ESCA	DFS	Median	III,IV	0.577	0.262	<.001	35	view →
ACC	DFS	Median	II,III,IV	0.398	0.669	.005	33	view →
MESO	OS	Quartile	All	0.278	0.538	.002	30	view →
UCS	OS	Median	IV	0.752	0.404	.013	30	view →
COAD	OS	Quartile	IV	1.000	0.239	.001	29	view →
UVM	OS	Median	All	0.410	0.842	.006	26	view →
STAD	DFS	Median	All	0.492	0.603	.021	25	view →
SARC	OS	Median	All	0.893	0.782	.003	10	view →
LIHC	DFS	Median	All	0.170	0.413	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IL4R–KIRP (DFS)

Open the KIRP breakdown →