IL4R

Across TCGA patient cohorts, IL4R mutation is significantly associated with the RNA expression of many other genes, with 3,173 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL4R-associated genes across cancer lineages are TAF9, HAUS1, and RAD17. Each is linked with IL4R in more than 2 cancer types. Because this analysis shows association rather than direction, both IL4R-to-partner and partner-to-IL4R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF9 grouped by IL4R-low versus IL4R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL4R→partner) and Y-score (partner→IL4R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF9 →	+0.690	+3.523	<.001	<.001	3	3
UCEC	HAUS1 →	+0.541	+2.721	.001	.003	3	3
UCEC	RAD17 →	+0.479	+2.559	<.001	<.001	3	3
UCEC	ZNF714 →	+0.509	+2.617	.007	.005	3	3
UCEC	LZIC →	+0.552	+2.403	<.001	<.001	3	3
UCEC	GNL3 →	+0.434	+3.914	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,173 associations by consensus.

TAF9 by IL4R expression — UCEC

Explore this box plot interactively →