IL4R

Across TCGA cell cohorts, IL4R RNA expression is significantly associated with the go_rna of many other GO terms, with 4,935 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IL4R-associated GO terms across cancer lineages are Interleukin-13-mediated signaling pathway, Response to interleukin-13, and Cellular response to interleukin-13. Each is linked with IL4R in more than 18 cancer types. Because this analysis shows association rather than direction, both IL4R-to-partner and partner-to-IL4R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interleukin-13-mediated signaling pathway grouped by IL4R-low versus IL4R-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL4R→partner) and Y-score (partner→IL4R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Interleukin-13-mediated signaling pathway →	+1.623	+1.770	<.001	<.001	3	19
BONE	Response to interleukin-13 →	+1.277	+1.554	<.001	<.001	3	16
BONE	Cellular response to interleukin-13 →	+1.229	+1.554	<.001	<.001	3	16
BREAST	Interleukin-4-mediated signaling pathway →	+0.301	+1.642	.005	<.001	3	14
OESOPHAGUS	Positive regulation of tyrosine phosphorylation of STAT protein →	+0.179	+1.650	.002	.006	3	12
OVARY	Response to interleukin-4 →	+0.159	+1.227	.002	.007	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,935 associations by consensus.

Interleukin-13-mediated signaling pathway by IL4R expression — BONE

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