IL4R

Across TCGA cell cohorts, IL4R mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL4R-associated genes across cancer lineages are TMEM174, IL17F, and SMIM23. Each is linked with IL4R in more than 1 cancer types. Because this analysis shows association rather than direction, both IL4R-to-partner and partner-to-IL4R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM174 grouped by IL4R-low versus IL4R-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL4R→partner) and Y-score (partner→IL4R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMEM174 →	+0.018	+4.930	.004	.008	3	1
URINARY_TRACT	IL17F →	+0.056	+5.087	<.001	.004	3	1
URINARY_TRACT	SMIM23 →	+0.013	+5.087	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	CFAP97D2 →	+0.023	+4.736	<.001	.009	3	1
STOMACH	FGF23 →	+0.053	+3.632	.007	.009	3	1
STOMACH	TSBP1 →	+0.043	+3.794	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

TMEM174 by IL4R expression — SOFT_TISSUE

Explore this box plot interactively →