IL4I1

Across TCGA pan-cancer cohorts, IL4I1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IL4I1 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher IL4I1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IL4I1 expression acts as an unfavorable survival marker.

KICH, DLBC, and LGG are the cancer types where IL4I1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
LGG	OS	Median	All	0.307	0.811	.008	6	view →
SKCM	DFS	Median	IV	0.040	0.454	.028	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LUAD	OS	Median	All	0.301	0.698	.045	3	view →
COAD	OS	Median	II,III,IV	0.506	0.792	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IL4I1–KICH (DFS)

Open the KICH breakdown →