IL4I1

Across TCGA patient cohorts, IL4I1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL4I1-associated genes across cancer lineages are PRAS40_pT246, 14-3-3_beta, and Fibronectin. Each is linked with IL4I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL4I1-to-partner and partner-to-IL4I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by IL4I1-low versus IL4I1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL4I1→partner) and Y-score (partner→IL4I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.217	+2.472	.008	.011	3	2
UCEC	14-3-3_beta →	-0.143	-2.973	.003	.035	3	1
UCEC	Fibronectin →	-0.369	-2.459	.020	.020	3	1
UCEC	MSH2 →	-0.342	-3.312	.002	.010	3	1
UCEC	NF2 →	+0.285	+3.000	.006	.036	3	1
UCEC	N-Ras →	-0.173	-3.571	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PRAS40_pT246 by IL4I1 expression — UCEC

Explore this box plot interactively →