IL4

Across TCGA cell cohorts, IL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 477 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL4-associated GO terms across cancer lineages are Regulation of MHC class II biosynthetic process, Positive regulation of type B pancreatic cell apoptotic process, and Regulation of intracellular protein transport. Each is linked with IL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both IL4-to-partner and partner-to-IL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of MHC class II biosynthetic process grouped by IL4-low versus IL4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL4→partner) and Y-score (partner→IL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of MHC class II biosynthetic process →	-0.103	-0.694	<.001	.002	3	4
LUNG_NSCLC_LUAD	Positive regulation of type B pancreatic cell apoptotic process →	-0.104	-0.107	.007	.003	3	4
BLOOD_Lymphoma	Regulation of intracellular protein transport →	+0.040	+1.564	.003	.002	3	3
CNS	Cell junction assembly →	+0.038	+0.186	.001	.003	3	3
BLOOD_Leukemia	Striated muscle cell proliferation →	-0.089	-0.714	<.001	.001	3	3
BLOOD_Leukemia	Regulation of glutamate secretion, neurotransmission →	+0.085	+0.653	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 477 associations by consensus.

Regulation of MHC class II biosynthetic process by IL4 expression — BLOOD_Leukemia

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