IL4

Across TCGA pan-cancer cohorts, IL4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IL4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where IL4 RNA is repressed in tumor relative to normal tissue. In most cancer types IL4 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

LUSC, THCA, and BRCA are the cancer types where IL4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.200	<.001	6	view →
THCA	All	All	+0.120	.009	4	view →
BRCA	Female	All	−0.111	.002	4	view →
ESCA	All	II,III,IV	+0.660	.026	2	view →
CHOL	All	All	+0.360	.009	2	view →
UCEC	All	All	−0.209	.042	2	view →
KICH	All	All	−0.105	.008	2	view →
KIRC	All	All	+0.043	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IL4–LUSC

Open the LUSC breakdown →