IL4

Across TCGA cell cohorts, IL4 mutation is significantly associated with the mutation status of many other genes, with 282 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL4-associated genes across cancer lineages are UPB1, LGALS1, and RABGGTA. Each is linked with IL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL4-to-partner and partner-to-IL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UPB1 grouped by IL4-low versus IL4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL4→partner) and Y-score (partner→IL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UPB1 →	+4.736	+5.560	.003	.003	1	1
BLOOD_Leukemia	LGALS1 →	+5.321	+5.894	.002	.002	1	1
BLOOD_Leukemia	RABGGTA →	+4.321	+5.285	.005	.005	1	1
BLOOD_Leukemia	MMP9 →	+4.321	+5.285	.005	.005	1	1
BLOOD_Leukemia	ADNP2 →	+4.736	+5.560	.003	.003	1	1
BLOOD_Leukemia	FGD1 →	+4.736	+5.560	.003	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 282 associations by consensus.

UPB1 by IL4 expression — BLOOD_Leukemia

Explore this box plot interactively →