IL37

Across TCGA patient cohorts, IL37 mutation is significantly associated with the RNA expression of many other genes, with 817 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL37-associated genes across cancer lineages are RNA5SP412, RN7SL148P, and KCNAB2. Each is linked with IL37 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL37-to-partner and partner-to-IL37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by IL37-low versus IL37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL37→partner) and Y-score (partner→IL37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.593	+2.382	<.001	.003	3	2
LUAD	RN7SL148P →	+0.098	+5.327	<.001	.002	3	2
UCEC	KCNAB2 →	+0.607	+3.223	.001	.009	3	2
UCEC	RPA3P1 →	+0.240	+2.479	<.001	.001	3	2
UCEC	RNU6-933P →	+0.385	+2.377	.004	.001	3	2
UCEC	IGLJ7 →	+1.562	+2.416	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 817 associations by consensus.

RNA5SP412 by IL37 expression — UCEC

Explore this box plot interactively →