IL37

Across TCGA pan-cancer cohorts, IL37 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of IL37’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL37 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL37 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

KIRC, BLCA, and LUAD are the cancer types where IL37 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL37 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.061	<.001	10	view →
BLCA	All	All	+0.227	<.001	8	view →
LUAD	Female	All	+2.383	<.001	7	view →
THCA	All	All	+0.493	.001	7	view →
STAD	Male	II,III,IV	+0.422	<.001	6	view →
LIHC	All	All	+0.100	.003	5	view →
ESCA	All	All	+0.778	.020	3	view →
KICH	All	All	+0.179	.005	3	view →
CHOL	All	All	+0.420	.007	2	view →
HNSC	Male	IV	+0.207	.008	2	view →
UCEC	All	IV	+0.175	.037	2	view →
BRCA	All	III,IV	+0.084	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

IL37–KIRC

Open the KIRC breakdown →