IL37

Across TCGA patient cohorts, IL37 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL37-associated genes across cancer lineages are Ku80, N-Ras, and ER-alpha_pS118. Each is linked with IL37 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL37-to-partner and partner-to-IL37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by IL37-low versus IL37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL37→partner) and Y-score (partner→IL37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.293	+2.335	.013	.020	3	2
UCEC	N-Ras →	-0.139	-2.308	.020	.036	3	2
SKCM	ER-alpha_pS118 →	-0.110	-1.874	.026	.049	3	1
UCEC	eIF4G →	+0.384	+3.000	.013	.036	3	1
UCEC	GATA6 →	-0.212	-2.985	.006	.034	3	1
UCEC	INPP4B →	-0.356	-2.999	.028	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Ku80 by IL37 expression — UCEC

Explore this box plot interactively →