IL37

Across TCGA cell cohorts, IL37 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IL37-associated genes across cancer lineages are LGALS2, MAGEB4, and CPB1. Each is linked with IL37 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL37-to-partner and partner-to-IL37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGALS2 grouped by IL37-low versus IL37-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL37→partner) and Y-score (partner→IL37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LGALS2 →	+0.482	+3.509	<.001	.008	3	1
SKIN	MAGEB4 →	+0.006	+4.022	<.001	.006	3	1
SKIN	CPB1 →	+0.141	+3.592	<.001	.006	3	1
SKIN	SVOP →	+0.051	+3.766	<.001	.004	3	1
SKIN	GSTA3 →	+0.480	+3.196	.006	.007	3	1
SKIN	CETN1 →	+0.006	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

LGALS2 by IL37 expression — SKIN

Explore this box plot interactively →