IL36RN

Across TCGA patient cohorts, IL36RN mutation is significantly associated with the RNA expression of many other genes, with 149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL36RN-associated genes across cancer lineages are SNX3P1Y, BNIP3P41, and RNU1-35P. Each is linked with IL36RN in more than 1 cancer types. Because this analysis shows association rather than direction, both IL36RN-to-partner and partner-to-IL36RN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX3P1Y grouped by IL36RN-low versus IL36RN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36RN→partner) and Y-score (partner→IL36RN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNX3P1Y →	+0.179	+5.478	<.001	<.001	3	2
PRAD	BNIP3P41 →	+0.039	+7.939	<.001	.008	3	2
PRAD	RNU1-35P →	+0.418	+7.939	<.001	.008	3	1
SKCM	OR4N5 →	+0.016	+3.993	<.001	.008	3	1
SKCM	SLC25A51P4 →	+0.024	+2.862	<.001	.006	3	1
SKCM	OR11G2 →	+0.018	+3.458	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 149 associations by consensus.

SNX3P1Y by IL36RN expression — UCEC

Explore this box plot interactively →