IL36RN

Across TCGA pan-cancer cohorts, IL36RN RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IL36RN data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher IL36RN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IL36RN expression acts as an unfavorable survival marker, although some lineages such as LUSC and HNSC show a favorable association.

BLCA, KICH, and LIHC are the cancer types where IL36RN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.351	0.604	.001	100	view →
KICH	OS	Quartile	All	0.588	0.934	<.001	58	view →
LIHC	OS	Tertile	All	0.522	0.721	.001	51	view →
UVM	DFS	Tertile	III,IV	0.212	0.734	.016	39	view →
UCEC	OS	Tertile	All	0.599	0.750	<.001	38	view →
KIRP	DFS	Quartile	All	0.520	0.885	<.001	37	view →
COAD	DFS	Median	IV	0.291	0.658	<.001	34	view →
BRCA	OS	Tertile	All	0.894	0.947	.002	32	view →
CHOL	DFS	Tertile	III,IV	0.095	0.562	.021	27	view →
PAAD	DFS	Tertile	All	0.388	0.579	.003	23	view →
STAD	DFS	Quartile	II,III,IV	0.466	0.704	.001	22	view →
LUSC	DFS	Tertile	II,III,IV	0.464	0.260	.005	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IL36RN–BLCA (DFS)

Open the BLCA breakdown →