IL36RN

Across TCGA patient cohorts, IL36RN mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL36RN-associated genes across cancer lineages are Ku80, Rab11, and C-Raf. Each is linked with IL36RN in more than 1 cancer types. Because this analysis shows association rather than direction, both IL36RN-to-partner and partner-to-IL36RN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by IL36RN-low versus IL36RN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36RN→partner) and Y-score (partner→IL36RN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.318	+3.013	.020	.019	3	1
UCEC	Rab11 →	-0.186	-3.000	.026	.037	3	1
UCEC	C-Raf →	+0.249	+3.000	.002	.037	3	1
UCEC	eIF4E →	+0.243	+3.000	.046	.037	2	1
UCEC	ER-alpha →	-1.142	-3.000	.016	.036	2	1
UCEC	4E-BP1_pT37_T46 →	-0.499	-3.000	.021	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Ku80 by IL36RN expression — UCEC

Explore this box plot interactively →