IL36RN

Across TCGA cell cohorts, IL36RN RNA expression is significantly associated with the go_rna of many other GO terms, with 1,829 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IL36RN-associated GO terms across cancer lineages are Rho protein signal transduction, Negative regulation of innate immune response, and Desmosome assembly. Each is linked with IL36RN in more than 8 cancer types. Because this analysis shows association rather than direction, both IL36RN-to-partner and partner-to-IL36RN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rho protein signal transduction grouped by IL36RN-low versus IL36RN-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36RN→partner) and Y-score (partner→IL36RN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Rho protein signal transduction →	+0.087	+0.754	<.001	.002	3	9
PANCREAS	Negative regulation of innate immune response →	+0.097	+0.609	<.001	<.001	3	9
OVARY	Desmosome assembly →	+0.279	+0.626	<.001	<.001	3	8
OESOPHAGUS	Release of cytochrome c from mitochondria →	+0.115	+1.436	.003	<.001	3	8
LARGE_INTESTINE	Plasma membrane organization →	+0.080	+0.952	<.001	<.001	3	8
LARGE_INTESTINE	Cell-substrate junction assembly →	+0.172	+0.861	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,829 associations by consensus.

Rho protein signal transduction by IL36RN expression — LUNG_NSCLC_LUAD

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