IL36G

Across TCGA patient cohorts, IL36G mutation is significantly associated with the RNA expression of many other genes, with 1,917 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL36G-associated genes across cancer lineages are RNA5SP393, RNU6-618P, and GJA1P1. Each is linked with IL36G in more than 2 cancer types. Because this analysis shows association rather than direction, both IL36G-to-partner and partner-to-IL36G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP393 grouped by IL36G-low versus IL36G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36G→partner) and Y-score (partner→IL36G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP393 →	+0.531	+3.766	<.001	<.001	3	3
LUAD	RNU6-618P →	+0.356	+3.468	.002	.005	3	2
UCEC	GJA1P1 →	+0.180	+2.669	.004	.003	3	2
SKCM	OR5B3 →	+0.014	+3.993	.002	.008	3	1
SKCM	OR51V1 →	+0.015	+3.993	<.001	.008	3	1
SKCM	RNU6-1169P →	+0.164	+3.140	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,917 associations by consensus.

RNA5SP393 by IL36G expression — UCEC

Explore this box plot interactively →