IL36A

Across TCGA pan-cancer cohorts, IL36A mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IL36A data layer compared with 18 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IL36A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IL36A expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC and LSCC are the cancer types where IL36A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.377	.022	9	view →
LSCC	DFS	Tertile	All	0.157	1.000	.010	7	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IL36A–HNSC (OS)

Open the HNSC breakdown →