IL36A

Across TCGA pan-cancer cohorts, IL36A RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IL36A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL36A RNA is repressed in tumor relative to normal tissue. In most cancer types IL36A is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, THCA, and LUSC are the cancer types where IL36A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL36A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−4.242	<.001	11	view →
THCA	All	All	+0.106	.002	7	view →
LUSC	Male	All	+1.223	<.001	6	view →
LUAD	All	All	+0.096	<.001	5	view →
KIRC	All	All	−0.036	.002	5	view →
PAAD	Male	All	+0.140	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IL36A–HNSC

Open the HNSC breakdown →