IL36A

Across TCGA patient cohorts, IL36A RNA expression is significantly associated with the go_rna of many other GO terms, with 6,890 significant associations in total. THCA shows the largest number of these associations.

The most reproducible IL36A-associated GO terms across cancer lineages are Regulation of T cell chemotaxis, Negative regulation of PERK-mediated unfolded protein response, and Establishment of skin barrier. Each is linked with IL36A in more than 10 cancer types. Because this analysis shows association rather than direction, both IL36A-to-partner and partner-to-IL36A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of T cell chemotaxis grouped by IL36A-low versus IL36A-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36A→partner) and Y-score (partner→IL36A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of T cell chemotaxis →	+0.084	+2.446	<.001	<.001	3	11
THYM	Negative regulation of PERK-mediated unfolded protein response →	+0.083	+1.158	<.001	<.001	3	10
STAD	Establishment of skin barrier →	+0.075	+0.881	<.001	<.001	3	10
ESCA	Epidermal cell differentiation →	+0.068	+3.552	<.001	<.001	3	10
STAD	Prostanoid biosynthetic process →	+0.066	+0.382	<.001	.007	2	11
STAD	Regulation of type 2 immune response →	+0.046	+0.655	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,890 associations by consensus.

Regulation of T cell chemotaxis by IL36A expression — ESCA

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