IL36A

Across TCGA patient cohorts, IL36A protein abundance is significantly associated with the RNA expression of many other genes, with 3,105 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IL36A-associated genes across cancer lineages are DMXL2, CNFN, and SLURP1. Each is linked with IL36A in more than 1 cancer types. Because this analysis shows association rather than direction, both IL36A-to-partner and partner-to-IL36A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL36A versus DMXL2 in HNSC, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36A→partner) and Y-score (partner→IL36A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DMXL2 →	-0.622	-0.753	.004	.002	3	2
LSCC	CNFN →	+1.461	+0.923	.003	.001	3	2
LSCC	SLURP1 →	+1.954	+1.660	.001	<.001	3	2
HNSC	ZNF780B →	-0.805	-0.861	<.001	<.001	3	2
HNSC	TM6SF1 →	-0.668	-0.763	<.001	.002	3	2
LSCC	IL36G →	+2.213	+1.074	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,105 associations by consensus.

IL36A vs DMXL2 — HNSC

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