IL36A

Across TCGA patient cohorts, IL36A mutation is significantly associated with the RNA expression of many other genes, with 237 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IL36A-associated genes across cancer lineages are RNU1-57P, RNA5SP281, and H2AB3. Each is linked with IL36A in more than 1 cancer types. Because this analysis shows association rather than direction, both IL36A-to-partner and partner-to-IL36A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-57P grouped by IL36A-low versus IL36A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36A→partner) and Y-score (partner→IL36A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU1-57P →	+0.543	+5.026	<.001	.009	3	2
STAD	RNA5SP281 →	+0.312	+5.026	.003	.009	3	2
SKCM	H2AB3 →	+0.021	+4.816	<.001	.001	3	2
SKCM	SRXN1 →	+0.582	+2.366	<.001	.003	3	1
SKCM	MIR6814 →	+0.593	+2.502	.001	<.001	3	1
LUAD	RNA5SP204 →	+0.789	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 237 associations by consensus.

RNU1-57P by IL36A expression — STAD

Explore this box plot interactively →