IL36A

Across TCGA patient cohorts, IL36A mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IL36A-associated genes across cancer lineages are CD8+ naive T-cells, Endothelial cells, and Melanocytes. Each is linked with IL36A in more than 1 cancer types. Because this analysis shows association rather than direction, both IL36A-to-partner and partner-to-IL36A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ naive T-cells grouped by IL36A-low versus IL36A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36A→partner) and Y-score (partner→IL36A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CD8+ naive T-cells →	-0.024	-1.788	.046	.027	3	1
SKCM	Endothelial cells →	-0.031	-2.255	.049	.035	3	1
SKCM	Melanocytes →	+0.074	+2.353	.002	.003	3	1
SKCM	mv Endothelial cells →	-0.023	-3.400	.034	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD8+ naive T-cells by IL36A expression — SKCM

Explore this box plot interactively →