IL36A

Across TCGA cell cohorts, IL36A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,660 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL36A-associated GO terms across cancer lineages are Regulation of tumor necrosis factor-mediated signaling pathway, Regulation of autophagy of mitochondrion, and Spliceosomal tri-snRNP complex assembly. Each is linked with IL36A in more than 4 cancer types. Because this analysis shows association rather than direction, both IL36A-to-partner and partner-to-IL36A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of tumor necrosis factor-mediated signaling pathway grouped by IL36A-low versus IL36A-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36A→partner) and Y-score (partner→IL36A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.101	+0.032	<.001	.003	3	5
PANCREAS	Regulation of autophagy of mitochondrion →	+0.064	+0.028	.002	.009	3	4
BLOOD_Leukemia	Spliceosomal tri-snRNP complex assembly →	+0.057	+0.490	<.001	.008	3	4
BLOOD_Leukemia	Protein-containing complex remodeling →	-0.089	-0.331	.002	.002	3	4
BLOOD_Leukemia	Regulation of cell cycle G1/S phase transition →	+0.067	+0.581	<.001	<.001	3	3
PANCREAS	Golgi disassembly →	+0.097	+0.053	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,660 associations by consensus.

Regulation of tumor necrosis factor-mediated signaling pathway by IL36A expression — PANCREAS

Explore this box plot interactively →