IL36A

Across TCGA cell cohorts, IL36A mutation is significantly associated with the mutation status of many other genes, with 125 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IL36A-associated genes across cancer lineages are XIRP1, ADAP1, and TLL1. Each is linked with IL36A in more than 1 cancer types. Because this analysis shows association rather than direction, both IL36A-to-partner and partner-to-IL36A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XIRP1 grouped by IL36A-low versus IL36A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL36A→partner) and Y-score (partner→IL36A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	XIRP1 →	+2.754	+4.189	.008	.008	1	2
LUNG_NSCLC_LUAD	ADAP1 →	+5.339	+4.772	.004	.004	1	2
LUNG_NSCLC_LUAD	TLL1 →	+3.602	+4.851	.002	.002	1	2
LUNG_NSCLC_LUAD	SORL1 →	+4.339	+4.339	.009	.009	1	1
LUNG_NSCLC_LUAD	DCAF5 →	+4.339	+4.339	.009	.009	1	1
LUNG_NSCLC_LUAD	MARVELD3 →	+5.339	+4.772	.004	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

XIRP1 by IL36A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →