IL34

Across TCGA patient cohorts, IL34 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL34-associated genes across cancer lineages are GMP, MEP, and lymphatic Endothelial cells. Each is linked with IL34 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL34-to-partner and partner-to-IL34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by IL34-low versus IL34-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL34→partner) and Y-score (partner→IL34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GMP →	+0.096	+2.806	<.001	.040	3	2
UCEC	MEP →	+0.036	+2.839	.016	.035	3	1
UCEC	lymphatic Endothelial cells →	-0.027	-3.116	.040	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GMP by IL34 expression — SKCM

Explore this box plot interactively →