IL34

Across TCGA pan-cancer cohorts, IL34 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IL34’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL34 RNA is repressed in tumor relative to normal tissue. In most cancer types IL34 is over-expressed in tumor, although a few such as HNSC and BLCA show the opposite, repressed pattern.

HNSC, BLCA, and KIRC are the cancer types where IL34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−2.127	<.001	12	view →
BLCA	Female	III,IV	−2.051	<.001	12	view →
KIRC	Female	III,IV	+1.554	<.001	12	view →
LUAD	Female	III,IV	−1.547	<.001	10	view →
LIHC	Female	All	+1.020	<.001	7	view →
BRCA	All	III,IV	−2.127	<.001	6	view →
UCEC	All	All	−1.724	<.001	6	view →
LUSC	Female	All	−1.350	<.001	5	view →
KICH	All	II,III,IV	−0.796	.024	3	view →
THCA	All	IV	−0.655	.022	3	view →
CHOL	All	All	+1.884	.001	2	view →
PRAD	All	All	−0.513	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IL34–HNSC

Open the HNSC breakdown →