IL33

Across TCGA pan-cancer cohorts, IL33 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IL33 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IL33 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IL33 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

KIRP, BRCA, and SKCM are the cancer types where IL33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.586	0.795	<.001	89	view →
BRCA	OS	Tertile	All	0.623	0.500	<.001	84	view →
SKCM	OS	Median	All	0.829	0.729	<.001	82	view →
LAML	DFS	Tertile	All	0.535	0.308	.006	32	view →
COAD	DFS	Median	II,III,IV	0.664	0.358	.001	31	view →
LIHC	OS	Quartile	All	0.893	0.717	.003	27	view →
KIRC	DFS	Quartile	III,IV	0.503	0.269	.005	26	view →
BLCA	OS	Median	All	0.663	0.756	.002	26	view →
LUAD	DFS	Tertile	All	0.886	0.753	.001	24	view →
SARC	OS	Quartile	All	0.868	0.567	<.001	21	view →
THCA	DFS	Quartile	IV	0.865	0.446	.004	19	view →
UCEC	OS	Median	IV	0.233	0.656	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IL33–KIRP (OS)

Open the KIRP breakdown →