IL2RG

Across TCGA patient cohorts, IL2RG mutation is significantly associated with the RNA expression of many other genes, with 1,592 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL2RG-associated genes across cancer lineages are SNORD127, RNA5SP408, and RNA5SP423. Each is linked with IL2RG in more than 1 cancer types. Because this analysis shows association rather than direction, both IL2RG-to-partner and partner-to-IL2RG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD127 grouped by IL2RG-low versus IL2RG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RG→partner) and Y-score (partner→IL2RG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD127 →	+0.386	+1.463	<.001	.008	3	2
LUAD	RNA5SP408 →	+0.308	+7.930	<.001	.008	3	2
UCEC	RNA5SP423 →	+0.609	+1.639	<.001	.006	3	2
UCEC	MIR4445 →	+0.114	+3.777	<.001	.007	3	2
BLCA	RNU6-40P →	+0.221	+4.433	<.001	.007	3	2
BLCA	MIR5696 →	+0.358	+3.971	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,592 associations by consensus.

SNORD127 by IL2RG expression — UCEC

Explore this box plot interactively →