IL2RG

Across TCGA cell cohorts, IL2RG mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL2RG-associated genes across cancer lineages are GML, H2BW1, and BHMT. Each is linked with IL2RG in more than 1 cancer types. Because this analysis shows association rather than direction, both IL2RG-to-partner and partner-to-IL2RG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by IL2RG-low versus IL2RG-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RG→partner) and Y-score (partner→IL2RG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.096	+3.567	<.001	.003	3	1
BLOOD_Leukemia	H2BW1 →	+0.048	+3.289	.004	.009	3	1
BLOOD_Leukemia	BHMT →	+0.196	+3.745	<.001	.005	3	1
BLOOD_Leukemia	OR1Q1 →	+0.367	+3.714	<.001	.005	3	1
BLOOD_Leukemia	TMEM196 →	+0.029	+3.289	<.001	.009	3	1
BLOOD_Leukemia	OR2Z1 →	+0.028	+3.475	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GML by IL2RG expression — BLOOD_Leukemia

Explore this box plot interactively →