IL2RB

Across TCGA patient cohorts, IL2RB mutation is significantly associated with the RNA expression of many other genes, with 631 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL2RB-associated genes across cancer lineages are LINC02439, LINC02488, and SNRPBP1. Each is linked with IL2RB in more than 1 cancer types. Because this analysis shows association rather than direction, both IL2RB-to-partner and partner-to-IL2RB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02439 grouped by IL2RB-low versus IL2RB-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RB→partner) and Y-score (partner→IL2RB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	LINC02439 →	+0.082	+5.902	<.001	.001	3	2
SKCM	LINC02488 →	+0.091	+2.359	<.001	.004	3	2
BRCA	SNRPBP1 →	+0.201	+4.707	<.001	.003	3	2
SKCM	SNORD116-25 →	+0.198	+2.191	<.001	.007	3	2
SKCM	RN7SL471P →	+0.604	+2.119	<.001	.003	3	2
UCEC	NME1-NME2 →	+0.478	+1.901	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 631 associations by consensus.

LINC02439 by IL2RB expression — LIHC

Explore this box plot interactively →