IL2RB

Across TCGA pan-cancer cohorts, IL2RB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IL2RB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL2RB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL2RB is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

KIRC, STAD, and KIRP are the cancer types where IL2RB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL2RB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.869	<.001	12	view →
STAD	All	II,III,IV	+1.449	.001	7	view →
KIRP	All	All	+1.038	<.001	6	view →
KICH	All	All	+0.935	<.001	6	view →
HNSC	All	All	+0.708	.002	6	view →
COAD	Female	All	−0.794	.001	4	view →
LUAD	All	IV	+1.084	.044	2	view →
THCA	All	IV	+1.014	.023	2	view →
LIHC	Male	All	−0.880	<.001	2	view →
LUSC	All	All	−0.589	.004	2	view →
BRCA	All	All	+0.340	.018	2	view →
ESCA	All	All	+1.643	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IL2RB–KIRC

Open the KIRC breakdown →