IL2RB

Across TCGA patient cohorts, IL2RB mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL2RB-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and eIF4E. Each is linked with IL2RB in more than 1 cancer types. Because this analysis shows association rather than direction, both IL2RB-to-partner and partner-to-IL2RB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by IL2RB-low versus IL2RB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RB→partner) and Y-score (partner→IL2RB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.648	+1.604	.005	.041	3	2
UCEC	4E-BP1 →	+0.297	+3.169	.005	.018	3	2
UCEC	eIF4E →	+0.200	+2.000	.015	.010	3	1
UCEC	MEK1 →	+0.466	+3.321	.001	.009	3	1
UCEC	Notch1 →	+0.111	+1.750	.045	.049	3	1
UCEC	p62 Lck ligand →	+0.395	+3.916	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Caspase-7-cleavedD198 by IL2RB expression — UCEC

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