IL2RB

Across TCGA cell cohorts, IL2RB mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL2RB-associated genes across cancer lineages are CARTPT, NOBOX, and KRTAP13-4. Each is linked with IL2RB in more than 1 cancer types. Because this analysis shows association rather than direction, both IL2RB-to-partner and partner-to-IL2RB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARTPT grouped by IL2RB-low versus IL2RB-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RB→partner) and Y-score (partner→IL2RB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CARTPT →	+0.017	+5.266	<.001	.001	3	1
BLOOD_Leukemia	NOBOX →	+0.072	+5.539	<.001	.003	3	1
BLOOD_Leukemia	KRTAP13-4 →	+0.045	+5.539	<.001	.003	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CARTPT by IL2RB expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →