IL2RA

Across TCGA patient cohorts, IL2RA mutation is significantly associated with the RNA expression of many other genes, with 915 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL2RA-associated genes across cancer lineages are RNU6-1274P, BPNT2P, and FAM230J. Each is linked with IL2RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL2RA-to-partner and partner-to-IL2RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1274P grouped by IL2RA-low versus IL2RA-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL2RA→partner) and Y-score (partner→IL2RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-1274P →	+0.547	+5.925	<.001	.002	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2
READ	FAM230J →	+0.026	+6.257	<.001	.001	3	2
UCEC	NR2C2AP →	+0.453	+2.627	.002	.005	3	2
SKCM	RNA5SP64 →	+0.154	+3.614	<.001	.002	3	2
SKCM	MIR517B →	+0.180	+4.163	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 915 associations by consensus.

RNU6-1274P by IL2RA expression — READ

Explore this box plot interactively →